INCI Name
Calcium Disodium EDT...
Functions
1 Roles
Sustainability
3/10
Category
chelating agents
What It Does
Calcium Disodium EDTA is the calcium-disodium salt of ethylenediaminetetraacetic acid, a synthetic aminopolycarboxylic acid chelator approved under 21 CFR 172.135 for use in food systems. Unlike its disodium EDTA counterpart, the pre-loaded calcium form is specifically preferred in food and cosmetic applications because it reduces the risk of calcium depletion from biological tissues while still effectively sequestering pro-oxidant trace metals such as iron and copper. Formulators choose Calcium Disodium EDTA over free-acid EDTA salts in pigment-rich emulsions and dressings precisely because its calcium-exchange mechanism allows it to outcompete Fe²⁺/Cu²⁺ for coordination sites without significantly disturbing the overall mineral balance of the formulation.
Technical Properties
pH Range
4.0-8.0
Optimal working range
Ionic Charge
anionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Foaming Ability
none
Lather generation
Ingredient Compatibility
Known Interactions
EDTA is a strong chelator that can strip copper from peptide complexes, deactivating GHK-Cu. Avoid EDTA as a chelating agent in copper peptide formulations; use a non-competing alternative.
Calcium inhibits both heme and non-heme iron absorption by 50-60% when taken together. These minerals compete for the same absorption pathways. Separate by at least 2 hours or formulate for different serving times.
High-dose Calcium (>600mg) can reduce Zinc absorption by 30-50%. Consider separating doses or using chelated zinc (zinc bisglycinate) for better absorption.
Calcium and Magnesium compete for absorption at high doses. While they can be combined at moderate levels, high-dose formulations should separate them or use chelated forms.
High Calcium + Citric Acid can form calcium citrate precipitate in beverages, causing cloudiness or sedimentation. Manageable with proper formulation (sequestrants, pH control), but test stability.
Sustainability Profile
Sustainability Score
Biodegradability
not readily biodegradable
Source
synthetic
Feedstock
Synthesized from ethylenediamine, formaldehyde, and sodium cyanide, with calcium salt incorporation; entirely petrochemical and synthetic in origin
Quick Reference
- Full INCI Name
- Calcium Disodium EDTA
- Common Name
- Calcium Disodium EDTA
- Category
- chelating agents