Copper Tripeptide-1 (GHK-Cu Solution) - conditioning, antioxidant

INCI Name

Copper Tripeptide-1

Functions

2 Roles

Sustainability

6/10

What It Does

Copper Tripeptide-1 is a synthetic peptide complex consisting of the tripeptide glycyl-L-histidyl-L-lysine bound to a copper ion (Cu2+). Originally discovered in human plasma and later found to decline with age, this blue-colored peptide is valued in anti-aging formulations for its ability to support collagen synthesis and provide antioxidant benefits. Formulators choose GHK-Cu for its dual action of promoting skin repair processes while protecting against oxidative damage, making it a premium active ingredient in sophisticated skincare products.

Improves slip and manageability

Reduces static and frizz

Adds shine and smoothness

Protects from mechanical damage

Technical Properties

pH Range

5.0-7.0

Optimal working range

Ionic Charge

cationic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Ingredient Compatibility

Known Interactions

ASCORBIC ACIDIncompatibleChelation

Ascorbic Acid reduces Cu2+ to Cu1+, deactivating copper peptides and generating free radicals via Fenton-like reactions. These must not be combined.

RETINOLUse CautionChelation

Copper peptides and Retinol operate through competing pathways (copper promotes collagen synthesis while retinol increases cell turnover). Combined use may increase irritation and reduce peptide stability.

GLYCOLIC ACIDUse CautionChelation

Low pH from Glycolic Acid can destabilize the copper-peptide bond, releasing free copper ions. Use in separate products.

EDTAUse CautionChelation

EDTA is a strong chelator that can strip copper from peptide complexes, deactivating GHK-Cu. Avoid EDTA as a chelating agent in copper peptide formulations; use a non-competing alternative.

ZINCUse CautionAbsorption Competition

Zinc competes with Copper for absorption via metallothionein binding. High zinc supplementation (>40mg) without copper can induce copper deficiency. If combining, maintain a Zn:Cu ratio of 8-15:1.

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