Methylcobalamin (Vitamin B12) - Supports energy metabolism and cognitive function

INCI Name

Methylcobalamin

Functions

1 Roles

Sustainability

7/10

What It Does

Methylcobalamin is the bioactive, coenzyme form of vitamin B12 that contains a methyl group directly attached to the cobalt ion, making it immediately usable by cells without metabolic conversion. Unlike cyanocobalamin (the synthetic form), methylcobalamin is naturally occurring and photosensitive, requiring careful formulation in opaque or amber packaging. In cosmetics, formulators choose this premium form for its superior stability in topical applications and its role in cellular regeneration, DNA synthesis, and supporting skin barrier function through its involvement in lipid metabolism.

Enhances formula performance

Contributes to product quality

Supports formulation goals

Improves user experience

Technical Properties

pH Range

4.0-7.0

Optimal working range

Ionic Charge

cationic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Ingredient Compatibility

Works Well With

nonionic surfactantshumectantspeptidesmost emollientsantioxidants

Avoid Combining

strong oxidizersvitamin C in high concentrationscopper ionsiron saltsreducing agents

Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

7/10

Biodegradability

readily biodegradable

Source

fermentation

Feedstock

bacterial fermentation using specific microorganisms

Available Variants

2 forms available

Powder

Powder 1% Trituration

Quick Reference

Full INCI Name: Methylcobalamin
Common Name: Vitamin B12
CAS Number: 13422-55-4
Category: actives

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