Palmitoyl Tetrapeptide-7

Palmitoyl Tetrapeptide-7 is a synthetic peptide consisting of four amino acids (glycine-glutamine-proline-arginine) attached to palmitic acid for enhanced skin penetration. Originally developed as Rigin, it works by modulating interleukin-6 (IL-6) production to reduce inflammation and prevent glycation damage, making it particularly effective in anti-aging formulations targeting mature or sun-damaged skin. Formulators choose this peptide for its clinically demonstrated ability to reduce the appearance of fine lines while calming inflammation, often pairing it with Palmitoyl Oligopeptide (as Matrixyl 3000) for synergistic collagen-boosting effects.