Palmitoyl Tripeptide-1 (and) Palmitoyl Tetrapeptide-7

Matrixyl 3000 is a synergistic peptide complex combining palmitoyl tripeptide-1 (pal-GHK) and palmitoyl tetrapeptide-7 (pal-GQPR), developed by Sederma as a biomimetic signal peptide system. The palmitic acid lipid chain enhances skin penetration of these short peptides, which are designed to stimulate collagen synthesis and modulate inflammatory responses in aging skin. Formulators choose this combination specifically because the two peptides work synergistically—palmitoyl tripeptide-1 promotes collagen and glycosaminoglycan production while palmitoyl tetrapeptide-7 helps reduce interleukin-6 production, making it particularly effective for addressing fine lines and improving skin firmness.