Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Matrixyl 3000 is a synergistic peptide complex combining palmitoyl tripeptide-1 (pal-GHK) and palmitoyl tetrapeptide-7 (pal-GQPR), developed by Sederma to target visible signs of aging. The palmitic acid lipid chain enhances skin penetration of these signal peptides, which work to stimulate collagen synthesis and modulate inflammatory responses in the dermal matrix. This specific combination became one of the most widely studied and commercially successful anti-aging peptide complexes, with clinical data showing improvements in wrinkle depth and skin firmness when used at 3-8% concentrations.