Palmitoyl Tripeptide-5

Palmitoyl Tripeptide-5 is a synthetic matrikine-mimetic peptide consisting of lysine-threonine-threonine sequence attached to palmitic acid for enhanced skin penetration. It works by stimulating transforming growth factor-beta (TGF-β), which signals fibroblasts to increase collagen production, particularly types I, III, and IV. Formulators choose this peptide for its clinically demonstrated ability to improve skin firmness and reduce the appearance of wrinkles, with the palmitoyl lipid chain providing both stability and improved delivery through the stratum corneum compared to non-lipidated peptides.