INCI Name
Polydeoxyribonucleot...
Functions
1 Roles
Sustainability
6/10
Category
actives
What It Does
Polydeoxyribonucleotide (PDRN) is a purified extract of low molecular weight DNA fragments (50-1500 kDa) derived from salmon sperm or milt, containing specific nucleotide sequences that activate adenosine A2A receptors in human skin cells. This biocompatible biopolymer is unique among cosmetic actives because it directly stimulates fibroblast proliferation and VEGF (vascular endothelial growth factor) production through purinergic receptor activation, making it particularly effective for wound healing and tissue regeneration. Formulators choose pharmaceutical-grade lyophilized PDRN for its proven clinical efficacy in promoting neocollagenesis and its ability to enhance cellular metabolism without the immunogenic concerns associated with larger DNA molecules.
Technical Properties
pH Range
6.0-8.0
Optimal working range
Ionic Charge
anionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Ingredient Compatibility
Works Well With
Avoid Combining
Sustainability Profile
Sustainability Score
Biodegradability
readily biodegradable
Feedstock
salmon sperm/milt
Available Variants
5 forms available
Lyophilized Powder (Pharmaceutical Grade)
Lyophilized Powder reconstituted in Water, Salmon-Derived, Cosmetic Grade
Lyophilized Powder, Pharmaceutical Grade (Salmon-Derived)
Lyophilized Powder, Pharmaceutical Grade, Pre-Dispersed in Squalane
PDRN Powder (salmon milt-derived, 50mg per serving, pharmaceutical grade)
Quick Reference
- Full INCI Name
- Polydeoxyribonucleotide
- Common Name
- PDRN (Salmon DNA)
- Category
- actives