INCI Name
3,3'-Diindolylmethan...
Functions
1 Roles
Sustainability
7/10
Category
actives
What It Does
3,3'-Diindolylmethane (DIM) is a naturally occurring phytochemical formed during the digestion and metabolism of indole-3-carbinol, a compound found in cruciferous vegetables such as broccoli, cauliflower, and Brussels sprouts. DIM is highly lipophilic and notoriously difficult to solubilize in aqueous systems, which is why microencapsulated or absorption-enhanced delivery forms are strongly preferred by formulators to achieve meaningful bioavailability. It is uniquely valued in nutricosmetic and ingestible wellness formulations for its ability to modulate estrogen metabolism pathways, specifically by shifting the balance toward the less proliferative 2-hydroxyestrone metabolite over 16α-hydroxyestrone.
Technical Properties
Ionic Charge
nonionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Foaming Ability
none
Lather generation
Molecular Profile
Molecular Weight
246.31
g/mol
LogP
4.30
Partition coefficient (lipophilicity)
H-Bond Donors
2
Hydrogen bond donor count
H-Bond Acceptors
0
Hydrogen bond acceptor count
Polar Surface Area
31.6
Angstroms squared
Ingredient Compatibility
Works Well With
Avoid Combining
Sustainability Profile
Sustainability Score
Biodegradability
readily biodegradable
Source
plant-derived
Feedstock
Cruciferous vegetables (e.g., Brassica oleracea species); synthesized via acid-catalyzed condensation of indole-3-carbinol for commercial scale
Related Ingredients
Similar provides 100mg dim per serving for estrogen metabolism support. clinically effective dose for promoting healthy 2-hydroxyestrone:16α-hydroxyestrone ratio. key differentiator for hormonal wellness positioning.s to explore
Quick Reference
- Full INCI Name
- 3,3'-Diindolylmethane
- Common Name
- DIM (3,3'-Diindolylmethane)
- Category
- actives