INCI Name
ACETYL HEXAPEPTIDE-1
Functions
2 Roles
Sustainability
6/10
Category
actives
What It Does
Acetyl Hexapeptide-1 is a synthetic hexapeptide composed of six amino acids with an acetyl group attached to the N-terminus, specifically designed to interact with melanocortin receptors involved in pigmentation regulation. It is primarily recognized for its ability to modulate skin pigmentation by influencing the MC1R receptor pathway, making it a targeted active for addressing uneven skin tone and hyperpigmentation. Formulators choose it for its dual utility in both skin-lightening formulations and as a peptide active that can complement other brightening agents such as vitamin C derivatives or niacinamide at low usage concentrations, typically between 0.001% and 0.1%.
Technical Properties
pH Range
5.0-7.0
Optimal working range
Ionic Charge
nonionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Foaming Ability
none
Lather generation
Molecular Profile
Molecular Weight
870.00
g/mol
LogP
0.90
Partition coefficient (lipophilicity)
H-Bond Donors
11
Hydrogen bond donor count
H-Bond Acceptors
9
Hydrogen bond acceptor count
Polar Surface Area
327.0
Angstroms squared
Ingredient Compatibility
Works Well With
Avoid Combining
Sustainability Profile
Sustainability Score
Biodegradability
readily biodegradable
Source
synthetic
Feedstock
Synthetically produced peptide chain derived from amino acid building blocks, typically manufactured via solid-phase peptide synthesis
Related Ingredients
Similar conditionings to explore
Quick Reference
- Full INCI Name
- ACETYL HEXAPEPTIDE-1
- Common Name
- Acetyl Hexapeptide-1
- Category
- actives