ACETYL HEXAPEPTIDE-38

Acetyl Hexapeptide-38 is a synthetically engineered hexapeptide developed by Lipotec (now part of Lubrizol), commercially known as Progeline, designed to specifically target the dermal-epidermal junction (DEJ) by upregulating the expression of collagen XVII and laminin-332 — two structural proteins critical to anchoring the epidermis to the dermis and maintaining skin architecture. Unlike many firming peptides that act solely on dermal collagen, its unique mechanism addresses DEJ integrity, making it particularly relevant for addressing skin sagging and loss of structural cohesion associated with chronological aging and progerin accumulation. Formulators select it for its robust clinical backing, low effective use concentration (active peptide typically at 0.003–0.005% in finished formula), and its ability to synergize with other regenerative actives in multi-peptide anti-aging protocols.