actives

Arginine (and) Serine (and) Threonine (and) Proline

Amino Acid Complex

humectantconditioningskin protectant

INCI Name

Arginine (and) Serin...

Functions

3 Roles

Sustainability

8/10

Category

actives

What It Does

This specific blend of four amino acids — Arginine, Serine, Threonine, and Proline — is formulated to mimic the natural moisturizing factor (NMF) composition found in the stratum corneum, making it particularly effective at reinforcing the skin's own hydration mechanisms. Arginine contributes wound-healing and barrier-supporting properties, Serine and Threonine provide hygroscopic moisture-binding, while Proline is a key structural component of collagen and helps maintain skin elasticity and resilience. Formulators choose this complex for its synergistic multi-amino acid approach to hydration, skin barrier reinforcement, and compatibility with a wide range of cosmetic systems including serums, moisturizers, and hair care products.

Attracts moisture from the air
Provides deep, lasting hydration
Improves skin elasticity and plumpness
Enhances penetration of other actives

Technical Properties

pH Range

5.5-7.0

Optimal working range

Ionic Charge

zwitterionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Foaming Ability

none

Lather generation

Ingredient Compatibility

Known Interactions

DIHYDROXYACETONEIncompatiblemaillard_degradation

DHA undergoes Maillard browning with free amino acids on skin to produce melanoidins (the tan). Free amino acids IN THE FORMULA (aloe vera juice, hydrolyzed proteins, peptide complexes, amino acid blends) react with DHA pre-application, degrading the active and accelerating off-smell development over shelf life. Remove the amino-acid source, switch to glycerin/propanediol/sodium PCA for hydration, or use encapsulated DHA if the amino-acid ingredient is brand-critical.

Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

8/10

Biodegradability

readily biodegradable

Source

mixed

Feedstock

Typically derived from plant-based fermentation or hydrolysis of plant proteins such as wheat, corn, or soy; may also be produced via microbial fermentation

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