INCI Name
B Vitamin Premix (Th...
Functions
4 Roles
Sustainability
6/10
Category
actives
What It Does
This B Vitamin Premix is a pre-blended combination of six water-soluble B vitamins — Thiamine HCl (B1), Riboflavin (B2), Niacinamide (B3), Pyridoxine HCl (B6), Methylcobalamin (B12), and D-Calcium Pantothenate (B5) — each contributing distinct skin-supporting bioactivities such as barrier reinforcement, sebum regulation, brightening, and cellular energy metabolism support. The inclusion of Methylcobalamin, the bioactive coenzyme form of B12, distinguishes this premix from simpler blends, offering superior bioavailability compared to cyanocobalamin. Formulators choose this premix for its convenience in delivering a synergistic multi-vitamin complex in a single raw material, reducing handling complexity while targeting skin fatigue, uneven tone, and compromised barrier function in serums, toners, and treatment products.
Technical Properties
pH Range
4.0-7.0
Optimal working range
Ionic Charge
nonionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Foaming Ability
none
Lather generation
Ingredient Compatibility
Known Interactions
Niacinamide and L-Ascorbic Acid can interact at low pH, potentially forming nicotinic acid (causes flushing). They work optimally at different pH ranges (Niacinamide pH 5-7, Ascorbic Acid pH 2.5-3.5). Consider using a Vitamin C derivative stable at higher pH, or separate products.
Glycolic Acid's low pH (3.0-4.0) can convert Niacinamide to nicotinic acid, causing flushing and reduced efficacy. Use in separate products or buffer the pH above 4.5.
Calcium inhibits both heme and non-heme iron absorption by 50-60% when taken together. These minerals compete for the same absorption pathways. Separate by at least 2 hours or formulate for different serving times.
Ferulic Acid is typically formulated at low pH (2.5-3.5) with Vitamin C, while Niacinamide works at pH 5-7. Not a destructive interaction, but pH compromise reduces the benefit of one active.
High-dose Calcium (>600mg) can reduce Zinc absorption by 30-50%. Consider separating doses or using chelated zinc (zinc bisglycinate) for better absorption.
Calcium and Magnesium compete for absorption at high doses. While they can be combined at moderate levels, high-dose formulations should separate them or use chelated forms.
High Calcium + Citric Acid can form calcium citrate precipitate in beverages, causing cloudiness or sedimentation. Manageable with proper formulation (sequestrants, pH control), but test stability.
Sustainability Profile
Sustainability Score
Biodegradability
readily biodegradable
Source
mixed
Feedstock
Thiamine HCl and Pyridoxine HCl are typically synthetic; Riboflavin is commonly produced via microbial fermentation (Bacillus subtilis or Ashbya gossypii); Niacinamide is synthetically derived from niacin; Methylcobalamin is produced via fermentation; D-Calcium Pantothenate is synthetically derived from pantolactone and beta-alanine
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Quick Reference
- Full INCI Name
- B Vitamin Premix (Thiamine HCl, Riboflavin, Niacinamide, Pyridoxine HCl, Methylcobalamin, D-Calcium Pantothenate)
- Common Name
- Vitamin B Complex Premix
- Category
- actives