actives97% purity, fine yellow powder, sourced from Berberis aristata bark

Berberine Hydrochloride

Berberine HCl

AMPK activator and IGF-1 pathway modulator; supports glucose metabolism and metabolic homeostasis; caloric restriction mimetic synergistic with resveratrol

INCI Name

Berberine Hydrochlor...

Functions

1 Roles

Sustainability

7/10

Category

actives

What It Does

Berberine Hydrochloride is the salt form of berberine, a quaternary isoquinoline alkaloid extracted from the bark of Berberis aristata, giving it its characteristic bright yellow color and water solubility. In cosmetic formulations, it is valued as a bioactive ingredient that activates AMPK pathways at the cellular level, positioning it as a metabolic-signaling active with anti-aging and skin-balancing properties distinct from conventional antioxidants. Formulators select this 97% purity grade for its consistent potency and stability in aqueous systems, and it is frequently paired with resveratrol to leverage complementary caloric restriction mimetic mechanisms for advanced longevity-focused skincare.

Enhances formula performance
Contributes to product quality
Supports formulation goals
Improves user experience

Technical Properties

pH Range

3.0-6.0

Optimal working range

Ionic Charge

cationic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Foaming Ability

none

Lather generation

Ingredient Compatibility

Works Well With

nonionic emulsifiershumectantswater-soluble activespolysaccharide thickenersniacinamidepeptidesresveratrol

Avoid Combining

anionic surfactants at high concentrationsstrong oxidizing agentsalkaline pH systems above 7tannin-rich botanical extractshigh-concentration vitamin C formulations
Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

7/10

Biodegradability

readily biodegradable

Source

plant-derived

Feedstock

Berberis aristata (Indian barberry) bark extract, a renewable botanical source cultivated primarily in the Himalayan region

Quick Reference

Full INCI Name
Berberine Hydrochloride
Common Name
Berberine HCl
Category
actives

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Berberine Hydrochloride (Berberine HCl) - AMPK activator and IGF-1 pathway modulator; supports glucose metabolism and metabolic homeostasis; caloric restriction mimetic synergistic with resveratrol | Genie Ingredient Database