actives

Biotin

Vitamin B7

conditioning
CAS Number:58-85-5

INCI Name

Biotin

Functions

1 Roles

Sustainability

8/10

Category

actives

What It Does

Biotin, also known as Vitamin B7 or Vitamin H, is a water-soluble B-complex vitamin that serves as an essential cofactor for carboxylase enzymes involved in fatty acid synthesis and amino acid metabolism. In cosmetic formulations, particularly hair care products, biotin is valued for its role in keratin infrastructure, as it supports the production of keratin protein that forms the structural foundation of hair, skin, and nails. Formulators choose USP grade biotin for its high purity and stability in aqueous systems, though its actual penetration to active follicles when applied topically remains a subject of ongoing research, with most clinical evidence supporting oral supplementation for deficiency-related hair issues.

Improves slip and manageability
Reduces static and frizz
Adds shine and smoothness
Protects from mechanical damage

Technical Properties

pH Range

4.0-8.0

Optimal working range

Ionic Charge

zwitterionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Molecular Profile

Molecular Weight

244.31

g/mol

LogP

0.30

Partition coefficient (lipophilicity)

H-Bond Donors

3

Hydrogen bond donor count

H-Bond Acceptors

4

Hydrogen bond acceptor count

Polar Surface Area

104.0

Angstroms squared

PubChem CID

171548

View on PubChem

Ingredient Compatibility

Works Well With

nonionic surfactantshumectantsproteinsamino acidsmost emollientsconditioning agentspreservatives

Avoid Combining

strong oxidizersraw egg whites (avidin)highly alkaline solutions above pH 9
Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

8/10

Biodegradability

readily biodegradable

Source

fermentation

Feedstock

glucose from corn or sugarcane

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