INCI Name
Calcium Alpha-Ketogl...
Functions
1 Roles
Sustainability
6/10
Category
actives
What It Does
Calcium Alpha-Ketoglutarate (Ca-AKG) is the calcium salt of alpha-ketoglutaric acid, an endogenous metabolite and key intermediate in the Krebs (TCA) cycle that naturally declines with age in biological tissues. It gained significant attention following a 2020 study in Cell Metabolism demonstrating lifespan and healthspan extension in mice, and subsequent canine longevity research, positioning it as a novel longevity-focused active in nutricosmetic and topical anti-aging formulations. Formulators are drawn to Ca-AKG for its proposed ability to influence DNA methylation patterns and epigenetic age clocks, offering a mechanistically differentiated approach compared to conventional antioxidant or peptide-based anti-aging ingredients.
Technical Properties
pH Range
5.0-7.5
Optimal working range
Ionic Charge
anionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Foaming Ability
none
Lather generation
Ingredient Compatibility
Known Interactions
Calcium inhibits both heme and non-heme iron absorption by 50-60% when taken together. These minerals compete for the same absorption pathways. Separate by at least 2 hours or formulate for different serving times.
High-dose Calcium (>600mg) can reduce Zinc absorption by 30-50%. Consider separating doses or using chelated zinc (zinc bisglycinate) for better absorption.
Calcium and Magnesium compete for absorption at high doses. While they can be combined at moderate levels, high-dose formulations should separate them or use chelated forms.
High Calcium + Citric Acid can form calcium citrate precipitate in beverages, causing cloudiness or sedimentation. Manageable with proper formulation (sequestrants, pH control), but test stability.
Sustainability Profile
Sustainability Score
Biodegradability
readily biodegradable
Source
synthetic
Feedstock
Synthesized via chemical reaction of alpha-ketoglutaric acid with calcium carbonate or calcium hydroxide; alpha-ketoglutaric acid is typically produced through fermentation of glucose or chemical synthesis from petrochemical precursors
Available Variants
3 forms available
Anhydrous Fine Powder, >98% Purity
Calcium salt, fine crystalline powder, >98% purity
Powder
Quick Reference
- Full INCI Name
- Calcium Alpha-Ketoglutarate
- Common Name
- Calcium Alpha-Ketoglutarate (Ca-AKG)
- Category
- actives