reducing agent

DITHIODIGLYCOLIC ACID

reducing agent
CAS Number:505-73-7

INCI Name

DITHIODIGLYCOLIC ACI...

Functions

1 Roles

Sustainability

N/A

Category

reducing agent

What It Does

2,2'-Dithiodi(acetic) acid

Molecular Profile

Molecular Weight

182.20

g/mol

LogP

0.10

Partition coefficient (lipophilicity)

H-Bond Donors

2

Hydrogen bond donor count

H-Bond Acceptors

6

Hydrogen bond acceptor count

Polar Surface Area

125.0

Angstroms squared

PubChem CID

68164

View on PubChem

Ingredient Attributes

Ingredient Compatibility

Known Interactions

RETINOLUse CautionpH Conflict

Retinol combined with Glycolic Acid significantly increases irritation potential. The low pH required for Glycolic Acid (pH 3.0-4.0) destabilizes Retinol. Use in separate products.

NIACINAMIDEUse CautionpH Conflict

Glycolic Acid's low pH (3.0-4.0) can convert Niacinamide to nicotinic acid, causing flushing and reduced efficacy. Use in separate products or buffer the pH above 4.5.

COPPER TRIPEPTIDE-1Use CautionChelation

Low pH from Glycolic Acid can destabilize the copper-peptide bond, releasing free copper ions. Use in separate products.

SALICYLIC ACIDUse CautionIrritation Risk

Combining AHA (Glycolic) and BHA (Salicylic) at full concentrations significantly increases irritation risk and can compromise the skin barrier. If combining, reduce concentrations of both.

TRETINOINUse CautionIrritation Risk

Tretinoin and Glycolic Acid together cause severe irritation, dryness, and barrier damage. Use in separate routines.

ADAPALENEUse CautionIrritation Risk

Adapalene combined with Glycolic Acid increases irritation risk. While Adapalene is more stable than Tretinoin, the exfoliation synergy can compromise the skin barrier.

Compatibility analysis powered by OpenMix — open-source formulation science

Quick Reference

Full INCI Name
DITHIODIGLYCOLIC ACID
CAS Number
505-73-7
Category
reducing agent

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