actives

Alpha Lipoic Acid

Alpha Lipoic Acid (R/S-ALA)

antioxidantconditioningskin protectant

INCI Name

Alpha Lipoic Acid

Functions

3 Roles

Sustainability

6/10

Category

actives

What It Does

Alpha Lipoic Acid (ALA) is a naturally occurring organosulfur compound and potent universal antioxidant, unique in its ability to function in both aqueous and lipid environments due to its amphiphilic nature. It is notable for its capacity to regenerate other antioxidants such as vitamins C and E, and glutathione, making it exceptionally effective at combating oxidative stress in skin cells. Formulators prize ALA for its anti-glycation properties and its ability to visibly reduce fine lines and uneven skin tone, though its use requires careful formulation at low concentrations (0.1–1%) in acidic, light-protected systems to prevent oxidation and discoloration.

Neutralizes damaging free radicals
Protects skin from environmental stress
Prevents formula oxidation
Supports anti-aging benefits

Technical Properties

pH Range

3.5-6.0

Optimal working range

Ionic Charge

nonionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Foaming Ability

none

Lather generation

Ingredient Compatibility

Works Well With

nonionic emulsifiershumectantspeptidesvitamin C derivativesniacinamidemost emollientssilicones

Avoid Combining

strong oxidizing agentshigh pH systems above 7heavy metal ionsthiols and sulfhydryl compounds
Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

6/10

Biodegradability

readily biodegradable

Source

synthetic

Feedstock

Alpha lipoic acid is naturally found in mitochondria of all living cells but is commercially produced via chemical synthesis, typically starting from 6,8-dichlorooctanoic acid or through fermentation-assisted routes

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