actives

Caffeine

Caffeine

antioxidantconditioningskin protectant
CAS Number:58-08-2

INCI Name

Caffeine

Functions

3 Roles

Sustainability

8/10

Category

actives

What It Does

Caffeine is a naturally occurring purine alkaloid extracted from coffee beans, tea leaves, and other botanical sources. In cosmetic formulations, it's valued for its ability to temporarily constrict blood vessels, reducing puffiness and dark circles, particularly in eye care products, while also providing antioxidant protection against UV-induced free radicals. Formulators choose anhydrous caffeine powder for its high purity (typically 98-100%), excellent stability, and versatility in both water-based and anhydrous systems, with typical use concentrations ranging from 0.5-3%.

Neutralizes damaging free radicals
Protects skin from environmental stress
Prevents formula oxidation
Supports anti-aging benefits

Technical Properties

pH Range

5.0-7.0

Optimal working range

Ionic Charge

nonionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Molecular Profile

Molecular Weight

194.19

g/mol

LogP

-0.10

Partition coefficient (lipophilicity)

H-Bond Donors

0

Hydrogen bond donor count

H-Bond Acceptors

3

Hydrogen bond acceptor count

Polar Surface Area

58.4

Angstroms squared

PubChem CID

2519

View on PubChem

Ingredient Compatibility

Known Interactions

EPHEDRINEIncompatibleSafety Concern

Caffeine + Ephedrine combination is banned by FDA due to cardiovascular risk (hypertension, tachycardia, stroke). Never combine in any consumer product.

Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

8/10

Biodegradability

readily biodegradable

Source

plant-derived

Feedstock

coffee beans, tea leaves, guarana

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