INCI Name
Niacinamide
Functions
3 Roles
Sustainability
7/10
Category
actives
What It Does
Niacinamide is the amide form of vitamin B3 (nicotinic acid), synthesized through the reaction of nicotinic acid with ammonia. It's one of the most versatile and well-researched cosmetic actives, clinically proven to strengthen the skin barrier by increasing ceramide production, regulate sebum production, reduce hyperpigmentation by inhibiting melanosome transfer, and provide anti-inflammatory benefits. Formulators favor it for its exceptional stability across a wide pH range (unlike many vitamins), its compatibility with nearly all other ingredients, and its ability to deliver visible results at concentrations of 2-10% without causing irritation.
Technical Properties
pH Range
5.0-7.0
Optimal working range
Ionic Charge
nonionic
Molecular charge type
Viscosity Effect
neutral
Impact on formula thickness
Molecular Profile
Molecular Weight
122.12
g/mol
LogP
-0.40
Partition coefficient (lipophilicity)
H-Bond Donors
1
Hydrogen bond donor count
H-Bond Acceptors
2
Hydrogen bond acceptor count
Polar Surface Area
56.0
Angstroms squared
Ingredient Compatibility
Known Interactions
Niacinamide and L-Ascorbic Acid can interact at low pH, potentially forming nicotinic acid (causes flushing). They work optimally at different pH ranges (Niacinamide pH 5-7, Ascorbic Acid pH 2.5-3.5). Consider using a Vitamin C derivative stable at higher pH, or separate products.
Glycolic Acid's low pH (3.0-4.0) can convert Niacinamide to nicotinic acid, causing flushing and reduced efficacy. Use in separate products or buffer the pH above 4.5.
Ferulic Acid is typically formulated at low pH (2.5-3.5) with Vitamin C, while Niacinamide works at pH 5-7. Not a destructive interaction, but pH compromise reduces the benefit of one active.
Sustainability Profile
Sustainability Score
Biodegradability
readily biodegradable
Source
synthetic
Feedstock
nicotinic acid derivative
Related Ingredients
Similar antioxidants to explore
Quick Reference
- Full INCI Name
- Niacinamide
- Common Name
- Vitamin B3
- CAS Number
- 98-92-0
- Category
- actives