actives

ACETYL TETRAPEPTIDE-3

Acetyl Tetrapeptide-3

conditioningfilm former

INCI Name

ACETYL TETRAPEPTIDE-...

Functions

2 Roles

Sustainability

6/10

Category

actives

What It Does

Acetyl Tetrapeptide-3 is a synthetic biomimetic peptide composed of four amino acids with an acetyl group at the N-terminus, specifically designed to target hair follicle anchoring and scalp health. It works by stimulating extracellular matrix proteins such as laminin-5 and collagen IV in the dermal papilla, helping to strengthen the attachment of hair follicles to the scalp and reduce hair loss. Formulators choose it primarily for anti-hair loss and scalp treatment products, often combining it with other actives like biotinoyl tripeptide-1, as it addresses follicle anchoring through a distinct and complementary mechanism of action.

Improves slip and manageability
Reduces static and frizz
Adds shine and smoothness
Protects from mechanical damage

Technical Properties

pH Range

5.0-7.0

Optimal working range

Ionic Charge

nonionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Foaming Ability

none

Lather generation

Molecular Profile

Molecular Weight

509.60

g/mol

LogP

-3.00

Partition coefficient (lipophilicity)

H-Bond Donors

8

Hydrogen bond donor count

H-Bond Acceptors

8

Hydrogen bond acceptor count

Polar Surface Area

240.0

Angstroms squared

PubChem CID

11752568

View on PubChem

Ingredient Compatibility

Works Well With

humectantsnonionic surfactantsmost emollientsother peptidesbotanical extractswater-soluble actives

Avoid Combining

strong oxidizing agentsextreme pH conditionshigh concentrations of anionic surfactants
Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

6/10

Biodegradability

readily biodegradable

Source

synthetic

Feedstock

Synthetically produced tetrapeptide composed of acetylated amino acid sequence (Gly-His-Lys derivative), typically manufactured via solid-phase peptide synthesis

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