Acetyl Tetrapeptide-5

Acetyl Tetrapeptide-5 is a synthetic bioactive peptide composed of four amino acids (Gly-His-Gly-Lys) with an N-terminal acetyl group, specifically engineered to target puffiness and under-eye bags by inhibiting angiotensin-converting enzyme (ACE) activity, which helps reduce fluid accumulation and capillary permeability. It is also known to stimulate the synthesis of collagen IV and fibronectin, improving skin firmness and the integrity of the dermal-epidermal junction. Formulators choose it for targeted eye contour treatments and anti-puffiness serums, typically used at low concentrations (0.001–0.01%) where it delivers visible lifting and de-puffing benefits without irritation.