actives

Allantoin

Allantoin

skin protectantconditioning
CAS Number:97-59-6

INCI Name

Allantoin

Functions

2 Roles

Sustainability

7/10

Category

actives

What It Does

Allantoin is a white, odorless crystalline powder naturally found in comfrey root and botanical extracts, though commercially produced through urea oxidation. It's renowned for its keratolytic properties that promote cell proliferation and wound healing, while simultaneously soothing irritated skin and enhancing moisture retention. Formulators favor allantoin for its exceptional tolerance across all skin types, its stability in various pH ranges, and its ability to improve skin texture without causing sensitization, making it a staple in post-procedure, sensitive skin, and anti-aging formulations.

Creates protective barrier
Shields from environmental stress
Reduces irritation risk
Supports skin recovery

Technical Properties

pH Range

4.0-7.0

Optimal working range

Ionic Charge

nonionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Molecular Profile

Molecular Weight

158.12

g/mol

LogP

-2.20

Partition coefficient (lipophilicity)

H-Bond Donors

4

Hydrogen bond donor count

H-Bond Acceptors

3

Hydrogen bond acceptor count

Polar Surface Area

113.0

Angstroms squared

PubChem CID

204

View on PubChem

Ingredient Compatibility

Works Well With

most surfactantshumectantsemollientspreservativesbotanical extractspeptidesvitamins

Avoid Combining

strong oxidizershighly acidic formulations below pH 3
Compatibility analysis powered by OpenMix — open-source formulation science

Sustainability Profile

Sustainability Score

7/10

Biodegradability

readily biodegradable

Source

synthetic

Feedstock

urea oxidation or comfrey plant extraction

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