Calcium L-5-Methyltetrahydrofolate (Methylfolate (as Calcium L-5-Methyltetrahydrofolate)) - conditioning

INCI Name

Calcium L-5-Methylte...

Functions

1 Roles

Sustainability

7/10

What It Does

Calcium L-5-Methyltetrahydrofolate is the calcium salt of the biologically active, reduced form of folate (vitamin B9), representing the predominant circulating form of folate found naturally in the human body. Unlike synthetic folic acid, this ingredient is already in its metabolically ready state and does not require enzymatic conversion, making it directly bioavailable to skin cells. Formulators choose it for its role in supporting cellular proliferation, DNA synthesis, and repair processes in skin, positioning it as a premium active in anti-aging and skin renewal formulations.

Improves slip and manageability

Reduces static and frizz

Adds shine and smoothness

Protects from mechanical damage

Technical Properties

pH Range

5.0-7.5

Optimal working range

Ionic Charge

anionic

Molecular charge type

Viscosity Effect

neutral

Impact on formula thickness

Foaming Ability

none

Lather generation

Ingredient Compatibility

Known Interactions

IRONUse CautionAbsorption Competition

Calcium inhibits both heme and non-heme iron absorption by 50-60% when taken together. These minerals compete for the same absorption pathways. Separate by at least 2 hours or formulate for different serving times.

ZINCNoteAbsorption Competition

High-dose Calcium (>600mg) can reduce Zinc absorption by 30-50%. Consider separating doses or using chelated zinc (zinc bisglycinate) for better absorption.

MAGNESIUMNoteAbsorption Competition

Calcium and Magnesium compete for absorption at high doses. While they can be combined at moderate levels, high-dose formulations should separate them or use chelated forms.

CITRIC ACIDNotePrecipitation

High Calcium + Citric Acid can form calcium citrate precipitate in beverages, causing cloudiness or sedimentation. Manageable with proper formulation (sequestrants, pH control), but test stability.

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